This project is a complex basic science laboratory based trial. It concerns calcium metabolism inside smooth muscle, the same type of muscle as the uterus.
Various agents and drugs can affect certain proteins inside the muscles and also the calcium level in association with a protein called 'G' protein. Recent work in the laboratory has revealed elevated levels of these substances in pregnant human uterine muscle compared to non-pregnant uterine muscle.
Samples of normal uterine muscle and pregnant uterine muscle in different stages of pregnancy will be evaluated for their different constituents and comparisons made.
This could have a significant effect on pre term delivery i.e. birth before 37 weeks if it can be shown that this is the cause of the problem. Drugs could then be developed that will block pathways which cause patients to go into premature labour and stop the illnesses that mothers and babies have due to pre term labour.
There are many ways you can donate to Wellbeing of Women. Your donation will help us continue to fund research into all aspects of reproductive health.
Need to contact Wellbeing of Women?
wellbeingofwomen@rcog.org.uk
Tel: 020 7772 6400
Fax: 020 7724 7725